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Fasting and reduced appetite are characteristic of patients with IBS. This study examined the effect of ketogenic diets and high-fat diets on the symptoms and clinical features of IBS.
A single-blind study randomized 70 patients with IBS to receive a ketogenic diet (3.8 g fat per kg of body weight), a high-fat dietary intervention (9.9 g fat per kg of body weight), or a control diet (4.2 g fat per kg of body weight). All patients received 2 weeks of a 2-wk baseline period, and a final 2-wk period was administered once the first period had occurred (after a median of 2 years of follow-up). At baseline and at a minimum of 2 years follow-up, the patients were assessed by a 3 x 3 factorial design to establish the clinical features of IBS.
In IBS patients, reduced appetite, abdominal distention, pain
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