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An international team of scientists has revealed an unusual type of ‘metabolism’ – in which mitochondria can’t be damaged by hydrogen ions or free radicals, a process they say could herald the advent of a type of cell that’s a ‘self-regulating organ.’

The researchers discovered a type of mitochondrial ‘metabolic switch’ in living cells, which controls how much energy a cell produces – and as a result could have huge practical applications for the treatment of mitochondrial diseases.


In the new study, published in Nature Communications, researchers found one type of mitochondrial switch in the red blood cells of adult mice, a ‘pump-signaling molecule’ that regulates what happens in the cell.

Mitochondria produce energy through the oxidation of various kinds of molecules, including hydrogen ions; however, they also contain an important antioxidant enzyme called NADH which can oxidise the hydrogen ions produced by other types of mitochondria. The result is an explosion of NADH, but an overload of hydrogen ions – often the result of reactive oxygen species – causes inflammation and cancer.

The new research suggests that switching on mitochondrial ‘metabolism’ could help repair damage caused by reactive oxygen species.

In the mice study, as well as being a ‘pump-signaling molecule’ it also appears to be necessary for the mitochondria to make proteins. Mitochondria are an important part of the cell, but have many roles to perform too,

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